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51 GAC manuscripts published as of June 26, 2018

The Genetic Analysis Center (GAC) at the University of Washington, Seattle is the working arm of the Genetic Studies Committee (GSC) of the Hispanic Community Health Study / Study of Latinos (HCHS/SOL).  Please note:


The GAC and the GSC are led by Bruce Weir, Professor of Biostatistics, and Cathy Laurie, a senior principal research scientist at the University of Washington.


The GAC's approach was developed during its work as the Coordinating Center for the GENEVA and GARNET consortia.

The Genetic Analysis Center will perform genotypic data cleaning on genome-wide SNP microarray data for approximately 13,000 subjects for HCHS/SOL. The cleaned data, quality metrics and quality control report will be used for downstream analyses and posted on the Database of Genotypes and Phenotypes (dbGaP), which is housed at the National Center for Biotechnology Information (NCBI).

The GAC will impute genotypic data using a 1000 Genomes reference panel for downstream analysis and dbGaP posting.

The GAC provides statistical support to the HCHS/SOL genetic working groups that will publish papers focusing on risk factors and traits of interest for specific conditions.

The NIH Heart, Lung, and Blood Institute (NHLBI) program officials facilitate the achievement of scientific goals and provide institutional oversight and guidance to the project.